Reporter-tagged full length genes, FAP-tag®, FAP-tagged GPCRs.
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Fluorogen Activating Protein Technology
Fluorogen activating protein – FAP-tags® are a new class of small genetically encoded reporters that exhibit fluorescence only in the presence of micromolar concentrations of particular nontoxic soluble fluorogens. FAP-tags® allow the user to turn the fluorescent signal on and off by adding or removing fluorogen, or to change the signal wavelength by substituting one fluorogen for another. |
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GPCR Fluorogen Exchange Assays
GPCRs are an important class of proteins for therapeutic development. Spectra has a full line of tagged GPCRs and validated cell lines for GPCR Internalization, trafficking and screening. |
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GFP-tagged Mouse ES Cell Lines
These embryonic stem cell lines each harbor a single tagged gene that expresses a fluorescent fusion protein that is controlled by the native regulation of the cell. The tag is placed using a novel system known as CD-tagging. This system places the DNA carrying the tag into an intron of a gene creating a new exon in the process. This exon then incorporates the tag into transcripts and ultimately into proteins. |
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Custom Gene Tagging and Generation of Stable Cell lines
Our skilled molecular biologists provide expertise and innovation in designing and constructing new FAP-tagged GPCRs and creating and validating stable cell lines expressing these tagged GPCRs. Spectra can also screen compounds on our validated GPCR expressing cell lines. Contact us to discuss. |